The Length of SNCA Rep1 Microsatellite May Influence Cognitive Evolution in Parkinson’s Disease
نویسندگان
چکیده
Citation: Corrado L, De Marchi F, Tunesi S, Oggioni GD, Carecchio M, Magistrelli L, Tesei S, Riboldazzi G, Di Fonzo A, Locci C, Trezzi I, Zangaglia R, Cereda C, D’Alfonso S, Magnani C, Comi GP, Bono G, Pacchetti C, Cantello R, Goldwurm S and Comi C (2018) The Length of SNCA Rep1 Microsatellite May Influence Cognitive Evolution in Parkinson’s Disease. Front. Neurol. 9:213. doi: 10.3389/fneur.2018.00213 Lucia Corrado1, Fabiola De Marchi2, Sara Tunesi3,4, Gaia Donata Oggioni2,5, Miryam Carecchio2, Luca Magistrelli2, Silvana Tesei6, Giulio Riboldazzi5, Alessio Di Fonzo7, Clarissa Locci1, Ilaria Trezzi7, Roberta Zangaglia8, Cristina Cereda9, Sandra D’Alfonso1, Corrado Magnani3, Giacomo P. Comi7, Giorgio Bono5, Claudio Pacchetti8, Roberto Cantello2, Stefano Goldwurm6 and Cristoforo Comi2*
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Expansion of the Parkinson disease-associated SNCA-Rep1 allele upregulates human α-synuclein in transgenic mouse brain
Alpha-synuclein (SNCA) gene has been implicated in the development of rare forms of familial Parkinson disease (PD). Recently, it was shown that an increase in SNCA copy numbers leads to elevated levels of wild-type SNCA-mRNA and protein and is sufficient to cause early-onset, familial PD. A critical question concerning the molecular pathogenesis of PD is what contributory role, if any, is play...
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